1)

(May flower- A beautiful error in sexual reproduction ; Anthurium flower - Another error in sexual reproduction. Rose flowers,Mussaenda flowers, Jasmine flowers, Bougainvillea flowers and many otherflowers all are examples of failed sexual reproduction. Flowers incapable of producing seeds or seedlings are cammon in nature) 1) Growth is a sign of life, not a sign of death. it is common sense that growth is for creation not for destruction.Reproduction is a very important function of all living organisms. Many living organisms have two methods for reproduction . In some of them both methods are working while in others only one is working and the other one is dormant. The dormant one gets reactivated when the dominant one is not functioning properly.Over a period of time human sexual reproduction is restricted and the 'reproduction free period' in human life span has considerably increased. Often cancers ocuur in old age when reproduction is absent or insufficient.In the post menopausel women incidence of cancer is high. In a rose plant faulty sexual reproduction (flowering) occurs in tender young branches while we use matured old branches for asexual reproduction. When we remove the overhanging branches preventing natural asexual reproduction there is more flowering (sexual reproduction) from the new tender branches. We have almost similar situation in cancer.

Perhaps humans are the only living organism on earth strictly controlling reproduction and going to negative growth in many communities and countries.Besides the human fertility is reducing due to various causess. The semen quality and the testosteron levels are reducing in young men. Sexual reproduction and the attempts for sexual reproduction are reducing. Often the physiological reflexes for reproduction and instincts for reproduction are suppressed in young persons.Humans should marry and have a licence for reproduction! Over and above this several organisations and governments are encoraging even same sex marriages. The social system is incompatable with the physiological system as far as reproduction is concerned. Today cancer rate is rapidly increasing even among relatively young people. It is common sense to assume that the geneticaly unstable abnormal growth seen commonly in old and middle age people is the result of a natural attempt for an alternate type of reproduction. Due to the lack of all the required genes for asexual reproduction in humans, the growth process failed to achieve the asexual reproduction. The purpose of active growth is to create - not to kill. In cancer the desired creation could not be achieved, hence the cell multiplication and growth continues indefenitly leading to a fatal out come.The genetic instability and increasing number of mutations are signs of attempts for development of a perfect asexual reproduction process. (We know that during drug resistance,the bacteria develop several mutations to achive reproduction) During the development process of asexual reproduction several mutations occur. With about six mutations often cancer is formed (tumor may contain 2 to 8 driver genes). It is possible that as the number of mutations increase sufficiently asexual reproduction shall materialise! Hence I think that the unstoppable, genetically unstable cancer growth with several mutations, seen often when sexual reproduction is stopped, is a defective (incompletely developed) reproductive tissue evolved while attempting asexual reproduction. 2) Errors and mistakes in biological process are common.b> "Look around you at all the beauty,complexity and variety of life, We live in a world of mistakes governed by chance"( Sean B.Carroll).There are several flowers which can't produce a seed or seedling.

Humans have several fatal and non fatal errors in sexual reproduction process.Transgenders, chromosomal anomalies, sterility, complications during delivery, death of the mother and baby, still birth, miscarrages, molar pregnancy,ectopic pregnancy etc. are some of the important errors of sexual reproduction in humans. Hence it is possible that cancer - a genetically unstable growth - may be a fatal error while attempting for asexual reproduction (without adequate genes) to compensate for the shortage in sexual reproduction. Cancer seems to be an error during the micro evolution for asexual reproduction,often observed when sexual reproduction is very much distorted, insufficient or absent.When the life time reproductive success is low natural selection process shall work and try to extend the reproductive period in humans. But inspite of a fall in menarcheal age in women in the developed world reproduction rate is poor. The reduction in the age of menarche did not have the desired effect in humans.The sexual reproduction rate in humans remains even below replacement rate in many developed communities and nations. Hence attempts for asexual reproduction are made to prevent the extinction is a natural biological reaction! (Cancer is relatively more in developed nations.) But unfortunatly there are several genetic errors while developing the asexual reproduction process.We know that even in a fairly perfected sexual reproduction process of humans there are several errors. Molar pregnancy does not have an embryo. In this world of several biological errors cancer is one of the a fatal errors during the evolution of an asexual reproduction process in humans. 3) There are lots of similarities between embryogenesis and tumorigenesis.The p53 genes controll both tumorigenesis and embryogenesis.This gene often destroys {apoptosis) the cancer (the defective product of asexual reproduction) as soon as it is formed. In fact the manifested cancer is only a small fraction of the number of cancers formed. This destruction of early cancer is similar to the phenomenon of miscarriages of the biochemical pregnancy. Development of early embryo shares many similarities with cancer development in terms of both biological behaviour and molucular basis. ( Yanlei Ma et.all 2010). Scientists have recognised that these similarities are not accidental. Prof. Lloyd J Old from Ludwig institute for cancer research, New York branch USA, recognised these similarities and nicknamed cancer a 'somatic cell pregnancy'.We know that often the nick names reveal what the given name is not revealing! This is true as far as cancer is concerned. The cancer growth is agressive like the growth of placenta on uterine wall. The cancer growth is highly vascular like the gravid uterus. There is even a direct correlation btween the depth of placental invasion and spread of cancer from the primary site in all specieses.Cancer cells have free mobility like the ovum/sperm. Cancer cell are immobilised and spread can be blocked by peritumoral injection of lidocaine.(Tessa & Elizabeth). The occurance of twins or multiple pregnancies are uncommon . Similarly the occurance of multiple primary cancers is uncommon. (In fact one risk factor can cause several types of cancers) The Zika virus can recognise that cancer is an embryonic tissue. Meduloblastoma, a brain cancer is eaten by Zika virus, without damaging the normal brain tissue, as it is similar to embryonic brain tissue ( Zika virus do not eat adult brain). Oncologists are attempting even to use zika virus to destroy cancer (meduloblastoma) without damages to the normal brain tissue! Cancer cells have large nucleus like the sperm. These multiple embryonic charecterestics of cancer indicate that the genetically unstable cancer growth is a unaccomplished defective product of asexual reproduction. 4) The immune systems do not attack cancer as well as pregnancy Evading immune destruction is one of the emerging hallmarks of cancer.(D.Hanahan & R.Weinberg) When the watch dogs do nothing, the troublemaker is from with in the system. We use amniotic membranes for transplantation in burns of conjunctiva because the embryonic tissue is well tolerated by all the recepients. Abnormal pregnancy like ectopics and molar pregnancy are not attacked by immune watchdogs.Even the embryo transfered to a surrogate mother is not attacked by the immune systems. It is obvious that reproductive systems have a builtin ability to escape from immune attack. Since there is no immune attack on cancer growth, cancers are often asymptomatic during the early stages. The immune avasion capability (hallmark) of cancer can explain how accidently transplanted cancer cells are growing in another person without immune attack. Similarly cancer is getting transmited in dogs on contact with mucous membrane as in coitus and on biting as in Tasmania devils without any immune attack on the cells transmitted. Immune evassion by cancer can be easily explained only by the asexual reproduction hypothesis. Other hallmarks of cancer also point to the fact that cancer is a failed reproductive process. In fact there is not only immune evasion by cancer but also immune enhancement of cancer cell formation?! The enzyme APOBEC3A,a part of innate immune system enhancess mutations by manipulating the unstable genome of cancer cells! Hence the genetically unstable abnormal growth immune to immune attack is a defective product of asexual reproduction caused by multiple mutations. 5) It is a wellknown fact that cancer affects frequently the sex organs and reproductive organs. And gametogenic genes are seen in all types of cancers .

The reproductive organs form around 10% to 15 % of total body mass. But the vast majority of cancers ( Female breast, prostate, ovary,uterus,testes etc.) are affecting reproductive organs in spite of removal of many healthy reproductive organs to prevent cancer. It was observed that incidence of prostate cancer is less in men if there is frequent ejaculation. In women if the baby is not breast fed the physiological system shall interpret it as still birth or death of the baby immediately after birth and hence a failure of sexual reproduction. Cancer incidence is high only in the female breast and is more when they were not used to feed the baby. Many women in the vulnareble age group for cancer do not have the ovaries and uterus because of frequent prophylactic removal of these reproductive organs in the developed countries. Hence the real number cancers of ovary and uterus would have been much more than what is recorded in statistics in the developed world. I do agree that the lung cancer is one of the common cancers. But the number of lungs in a population is more than four times the number of prostates in a population.( Both men and women have two lungs each) And 80% of men over the age of 80 have prostate cancer. In a rose plant both sexual reproduction and asexual reproduction starts from the nodes. And only old branches are used for asexual reproduction indicating that cancer arising from old people could be an asexual reproduction process.The risk factors for cancer are often risk factors for infertility too. Cancer growth is not influenced by growth hormone,but often influenced by sexhormones. The telomeres of the DNA of cancer cells are long and the length shall not reduce by division. Telomers are long in the cells of embryo too. Normaly,Telomerase enzyme is present only in the germ cells.The presence of telomeraseses in cancer cells also poits to the reproductive nature of cancer. Interestingly the gametogenic genes ( cancer testes antigen) are seen normaly only in the testis, ovaries and placenta. They are typically required only for reproduction. Interestingly these genes are seen in different types of cancers. These genes are also known to promote cancer and are critical for the growth of the cancer. Why should gametogenic genes concerned with reproduction and a new life promote a killer disease like cancer? It shows that cancer - the genetically unstable growth promoted by gametogenic genes - is only a partly developed product of reproduction and it is neither an accidental error in cell division nor a typical growth disorder. 6) It was belived that cancer was occuring due to a random accident in cell division (DNA replication),in spite of the Peto's paradox.The lack of corelation between the body size (number of cells and cell divisions) and cancer risk (errors in cell division) is considere to be Peto's paradox. Theoreticall an elephant with lots of cells more than humans, shall have more cell divisions and should have more errors in cell division. But elephants do not have more incidence of cancer than human. And in humans cancer occurs when the cell divisions and growth have reduced considerably as in old age. When we consider that cancer is not a simple random accident but a failure during the attempt for asexual reproduction,Peto's paradox does not exist.Another paradox is that if cancer is just an error in cell division we should not have a precancerous condition gradually progressing to cancer. Several types of mutations are seen in bacteria to develop a new method of reproduction, when reproduction is blocked by antibiotics. Similar phenomenon is occuring in humans when sexual reproduction is scanty.Hence the genetically unstable cancer growth is the product of an unaccomplished asexual reproduction process, not occuring by random accident in the normal cell division but due to the failure during the attempt to develope additional reproductive process by mutation.To have identical error producing a growth with all hallmarks of cancer due to a simple error in cell division is unlikely, whereas an identical error producing a growth with all hallmarks of cancer in different persons while developing a difficult reproductive process could be more likely. The progression of precancerous growth to cancer also shows that the error in cancer is not a simple error in cell division.So It is an error in the process for asexual reproduction.

The asexual reproduction hypothesis can explain cancer growth and can eliminate all paradoxes in the existing hypothesis on cancer. 7) Contrary to the concept that cancer is a bunch of abnormal cells developed due to accident in cell division, cancer tissue contains not only the abnormal cells but also normal tissue like normal blood vessels and normal nerve fibres as if it is an organogenesis. (In malignant teratomas bone,cartilage,teeth etc. are also possible.) Hence we can consider that it is more than just an accident in cell division of a perticular tissue.Presence of normal tissue in cancer growth indicates that it is an attempt for organogenesis or embryogenesis. Since cancer is not just a bundle of cells of defective cell division, it is an attempt for formation of a new life or embryo. Hence cancer is a product of a failed attempt for asexual reproduction with abnormal as well as normal cells and it is attempting to develop a new life in the absence of essential asexual reproduction genes.It is an unfinished product of the reproduction process. 8) Spontaneous cure of cancer is a pleasant surprise while treating cancer. This is because cancer is a growth of embryonic tissue without the protection of placenta. The bacteria,virus, toxins and intoxicating substancess reaching the patients blood can affect the vulnerable reproductive tissue easily resulting in the spontaneous miscarriage of the asexual reproduction (somatic cell pregnancy). Oncologist are even planning to use the embryonic brain eating Zika virus to selectively destroy the brain cancer. (Viral oncolysis). Rubella virus,Measles virus,Herpes virus, Toxoplasma Gondi etc can easily attack the embryonic growth. We know that one in five pregnancies end up in miscarriages before 12th week.The existing hypothesis on cancer cannot explain the spontaneous cure of cancer. Spontaneous cure of cancer support the asexual reproduction hypothesis and spontaneous cure is not a rare incident. Often they are reported as miracle cure or faith healing and not documented in scientific publications. No other hypothesis can explain spontaneous cure or miracle cure of cancer.We know that several attempts for sexual reproduction can fail in humans resulting in miscarriages without any known cause or reason. (Spontaneous cure is the spontaneous miscarriage of the 'somatic cell pregnancy'!). 9) Usually,animals in the forest do not suffer from cancer because their life is not abnormaly extended beyond their reproductive period and their reproduction is not regulated by themselves or by any agents. But Tasmanian-devils and sea lions at the verge of extinction due to insufficient sexualreproduction are developing cancer. (They neither smoke nor drink alcohol nor eat sugar!) The Tasmania devil mothers do not produce sufficient milk to feed the babies and often all of them die of starvation. Over and above this the fossils of allready extinct dinosurus showed cancer! The presence of cancer in animals at the verge of extinction is an additional proof infavour of the hypothesis that cancer is a failed attempt for asexual reproduction due to the lack of sexual reproduction and or poor survival of the infants.It can be considered as a failed nature's attempt to improve reproduction by asexual reproduction and to save a species from extinction.Unfortunatly the attempt fails in the organisms illequiped with asexual reproduction genes.The real cause for cancer seems to be the deficiency of essential genes for asexual reproduction; or the presence of an incomplete set of asexual reproduction genes.

10) Parthenogenesis is known to occur in invertebrates,fish and reptiles whenever there is difficulty in sexual reproduction. It was observed that Zebra sharks were reproducing by asexual method when kept in captivity without a male partner. Parthenogenesis was confirmed in Zebra sharks by DNA studies in 2016. Recently(2021) in the state Kerala,in India a coconut tree started producing seedlings (saplings) instead of the coconuts. Almost all the coconuts produced by the trees are consumed by humans without allowing any seedling formation.While making toddy, an intoxicating drink from the bunch of flowers of the coconut tree, humans do not allow even the flowers of many coconut trees to bloom.Hence the coconut tree switched over to asexual reproduction. The asexual reproduction also starts from the sexual reproduction location of the coconut tree. When life time reproductive success is poor natural selection process works to evolve new method of reproduction.It is possible that before evolving a perfect asexual reproduction process the tree might have tried unsuccesfully asexual reproduction for last several years. These trees were most probably destroyed by the agriculterists as diseased trees because they were not producing coconuts.Here is another supporting evidence to show that attempts shall be made by living organisms to switch over from sexual reproduction to asexual reproduction when sexual reproduction is affected. Since the asexual reproduction process is more complex and difficult in mammals than the invertebrates, we get a genetically unstable growth called cancer - a defective product of asexual reproduction. And cancer is very rare among the lower animals which can succesfully switch over from sexual to asexual reproduction. The asexual reproduction hypothesis simplifies cancer and can explain most of the hallmarks of cancer as well as the risk factors of cancer. If cancer was due to the accumilation of mutations over a period of time why more than 18 types of cancers are linked to obesity? Similarly how infertility and undescended testicles become risk factors for cancer? It is evident that the real cause for cancer is the absence of essential asexual reproduction genes in humans associated with a strong drive and instinct for reproduction. According to Occam's principle the simplest answer to a problem could be the right answer rather than a sophisticated answer for a difficult question.(Principle of parsimony) However it is common sense that when a living organism fails to fully satisfy the very important reproductive needs of the species nature shall try another method to maintain a minimum reproduction level at least higher than the replacement rate.There is a relationship between the incidence of cancer and fertility. It seems that wherever the fertility rate is below the world average (Fert. rate 2.418 per woman) the cancer rate is above the world average (Can. rate 196 per 100K persons). Examples are South Korea (Fert. rate 0.78 per woman & Can.rate 239.9 per 100K) , Singapore ( Fert. rate 1.17 per woman & Can.rate 229.8 per 100k persons) and Italy (Fert. rate 1.24 per woman & Can.rate 278.3 per 100 K persons). And at the other end of the spectrum whenever fertility rate is above the world average cancer rate is below the world average. Example is Niger (Fert.rate 6.92 per woman & Can.rate 79 per 100K)! Recently it was observed that the early onset cancer rate is increasing in the world. The increase is predominantly in countries where fertility rate is low. South Korea and Japan are economically progressed Asian countries. It was noticed that the early onset colorectal cancer was increasing at a faster rate in South Korea where fertility rate was 0.78, than it was in Japan where Fertility rate was 1.39. I do agree that corelation does not mean causation . But in the presence of several other evidence favouring the asexual reproduction hypothesies, this corelation is significant.(The increase in cancer rate in S.Kore is not due to the increase in old age population because cancer rate peaks in the sixties and seventies not in very old age.)

In humans sex and sexual reproduction is reducing.In China and India,(the two most populated countries in the world) the fertility rate is reducing and cancer rate is increasing. This is influencing the world fertility rate! The world fertility rate is decreasing and the world cancer rate is increasing. (The BRCA 1 & 2 mutations linked to breast cancer are known to booster female fertility.) Reproduction is a very important function of any living organism including humans.Any adverse condition such as smoking, alcoholism, obesity and pollution greatly alter the reproductive health ( Encyclopedia of reproduction, vol.3, p.446-451). Interestingly these are the important risk factors for cancer too.The risk factors are not the cause for cancer.There is a strong association between obesity and infertility. Infertility is causing obesity or obesity is causing infertility? Either way obesity is an important risk factor for several types of cancer. Is obesity a preperation for cancer?(As the cancer advances often the obesity transforms to cancer cachexia) It was observed that women going on regular night duties get breast cancer more frequently. It is obvious that the these women can have less attempt for sexual reproduction. It is reasonable to expect that there shall be an alternate plan 'B' for reproduction for living organisms in nature. The male body with a pair of breast is only a modified female body capable of asexual reproduction and feeding the infant if required, hence asexual reproduction attempts (cancers) may occur in males too! Many men develop gynecomastia as the age advancess. Besides men are even losing the 'Y' chromosomes as sexual reproductive capability disappears due to ageing. We know that molar pregnancy has no embryo, yet it is an error of sexual reproduction.Similarly the 'somatic cell pregnancy' has no embryo, yet it is an error in asexual reproduction. Methotrexate is a drug used to destroy exclusively an ectopic pregnancy,an error in sexual reproduction with an embryo. The same drug is used to destroy cancers too, because both have several biological similarities. There are several types of sexual reproductive errors. Similarly there are several types of asexual reproduction errors - cancers.Are these reproductive errors due to bad luck? Whenever we do not know the cause for these errors we assume that it was due to bad luck. In biological science we can't prove results as in mathematics, physics or logic. We can only simply add the plausibility by accumilating more and more evidence. Statistics and commonsense support the asexual reproduction hypothesis. According to Sir Arthur Connan Doyle "The world is full of obvious things which nobody by any chance observe" I feel that the world is full of reproductive errors and cancer is one of the fatal reproductive errors.

For further details, you may read my E book "Why Cancer?" ISBN:9781370190973. smashwords.com/books/view/769583. OR Cancer : The asexual reproduction hypothesis. Journal of International Medical Science Academy, 2020,vol.33,No.1, Jan-Mar, p.37-39. www.imsaonline.com Make love not wars,you may prevent cancer too!

 

Young TXD hybrid coconut tree very active in reproduction!  

Why do cancer develop in certain animals in their natural habitat? Cancer is seen in Tasmanian Devils & Sea lions,  They neither smoke tobacco nor chew tobacco, they do not drink alcohol,  they do not eat fast food, there is no obesity and they breast feed their young ones. But still they develop cancer.  The fact is that most of these animals are at the verge of extinction. Their reproduction rate is low due to various reasons To prevent extinction due to the insufficient sexual reproduction these animals are attempting asexual reproduction. Several animals in the zoos die of cancer because at captivity their reproduction is very low due to various reasons. Recently a Zebra shark in captivity without a partner for sexual reproduction, reproduced asexually (parthenogenesis). Unfortunately in mammals this attempt for asexual reproduction fails due to the absence of asexual reproduction genes. This defective product of asexual reproduction is manifested as a genetically unstable growth; we call cancer. Paradoxically  instead of saving the animals from extinction these cancers enhance the extinction process because of the early death  of the animals due to cancer. Animals ( dragons, hammer head sharks zebra sharks etc.) which are able to reproduce succesfully rarely develop cancer. Here is another evidence to support  the hypothesis that cancer is a failed attempt for asexual reproduction. Is humans also at the verge of extinction ? Perhaps yes. Due to the intentional reduction of attempts for reproduction and the progressive deterioration of quality and quantity of sperms in men, sexual reproduction rate is deteriorating. Besides, those who have good sperm count undergo vasectomy for birth control . And it is estimated that majority of men shall not have reproductive capacity by 2060!! (Alex Ford, Reproductive health) That is the beginning of the journey to extinction.Perhaps the journey starts from Seoul in South Korea with a fertility rate of 0.63. And in South Korea cancer rate is 239.9 and it is the most common cause for death! Pandemics of fatal viral diseases shall enhance the process of extinction. 

Kerala, a small state in India has lots of coconut plantations. Millions of coconuts are being harvested for human consumption  every year since last several centuries. Every bit of the nut is used for human consumption. On several occasions the trees are not allowed   even to complete the flowering and nut formation, for the sake of extraction of  an intoxicating drink - the  toddy . This is being continued  uninhibited for last several centuries. Ultimately only very few nuts, from a few selected trees  are used for making seedlings and replanting. All the trees are producing nuts for growing  new trees as a part of the sexual reproduction. But unfortunately the reproduction process stops at the level of formation of seeds in a vast majority of trees. Germination is not allowed by humans! The trees react to this  diversion of  huge number of seeds from seedling formation to  human consumption. The result is,  the trees are making attempts for asexual reproduction by growing saplings from the nodes instead of  the bunch of male and female flowers. This was recently reported from Kerala (Mathrubhumi,8th April,2021). Perhaps similar attempts  might have been made for asexual reproduction in the previous years. And the farmers might have removed the unproductive and'diseased'trees without being reported! The farmers plant hybread coconut trees for getting more coconuts & they give good manure for getting more coconuts.The genes and the manure decide the productivity (reproduction) of coconut. It is important to recognise that nature always have a plan B for reproduction; the most important function of a living organism.   

 To know more about cancer and the new hypothesis , you may  please read the e book Why Cancer? ISBN:9781370190973.smashwords.com/books/view/769583 

OR Cancer: The asexual reproduction hypothesis. JIMSA 2020.Jan-Mar.vol.33,No.1,p37-39. www.imsaonline.com

1. 
   
    Odda days - The Norwegian Nostalgia is dedicated to my dear friend and relative late Mr. Ittyera, A. Tholath.    Certain memories never die.

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Young for ever, natural death never!

  The combination of 'Eye doctor out of the box'  ISBN: 9781301878284   and   'Why cancer' ISBN: 9781370190973.    e books     by Ittyerah Tholath

  Humans were afraid of death as and when they started living on the earth. As per records Gilgamesh, the legendary Mesopotamian king wanted to conquer death and live for ever. And his thoughts were carved on tablets written thousands of years before Christ. He hoped to conquer death , but could not achieve it. The immortality story of Hindu mythology is different. According to Hindu mythology Gods were mortal before drinking the 'Amrith' extracted by churning  the milky ocean. After drinking the 'amrith' they became young and immortal. Millions of believing Hindus go on pilgrimage to the places where 'amrith' was spilled over to become healthy and to live long. They take bath in the holy river hoping to become young and immortal. When we analyze  the mythology of Jews, Christians & Islam we see that  Adam & Eve were immortal  when created, and became mortal after eating the forbidden fruit. Hence as per mythology and religion humans can become immortal. There are scientific methods too to achieve immortality! 

Modern medical doctors try to extend life and have succeeded in increasing   life expectancy considerably. It means that they could  postpone death, but could not eliminate death and destruction. There is no organism on earth other than humans to have a health system. The health system has achieved the goal of extending life expectancy and reducing infant mortality rate. But it could not reduce the number of patients and unhappy people on the globe. (The microbes without a health system remains young and energetic throughout their life.) The patients are often unhappy with our health delivery system. the doctors and health professionals are unhappy and often depressed. And the suicide rate of doctors' is more than double of the general population. The governments are strained because expenditure on health system is increasing rapidly. Why does this happen ? Because the aim of health system is wrong. The aim of health system should be a disease free young world. And all efforts should be in that direction. Delaying death shall increase the strains on health system. And immortality does not mean  extension of the old age indefinitely.

   Scientifically immortality is possible if we can rejuvenate as age advances by undergoing binary fission before reaching senility. ( We have a glorious amoebic heritage & immortality is in our genes. Mature amoeba divide and transform to two young amoeba) Immortality is with in our reach, but can be achieved only by hard scientific work with passion. We have successfully transferred  genes from other living organisms. And  editing of DNA and genes are being done in many labs. We have even edited the genes of human embryo successfully. Germ line editing, and  incorporating binary fission genes is the next step. Hence with in few decades human immortality by incorporating binary fission genes  will be a reality. Humans , 'being mortal', suffer  from a lot of   health problems and finally they are  leading them to a miserable death. Humans becoming old leads to several geriatric  diseases. Old population is vulnerable to many diseases including the COVID-19.  Hence to become young and immortal is a necessity not only to prevent death but also for enjoying good health. We can adopt God's own ways for attaining immortality-- churning  the ocean of genes and extract all the appropriate genes for the binary fission. Once these genes were incorporated in human genome humans can divide and become young as the age advances! 36 years is the average life expectancy of humans in unprotected environment and if we can divide at 36 years there will not be any old humans! Becoming young by division is nature's law. If we follow the natures way immortality is not impossible!   

 Both the books refer to the possibilities of immortality by changing genes (germ line transfer), changing style of procreation, and transformation. Asexual reproduction hypothesis of cancer origin was published in the Journal of International medical science Academy (www.jimsaonline.com or www.imsaonline.com). HeLa cells , the cells derived from the cancer patient , Henrietta Lacks have become immortal and are continuing to live in laboratories many years after the death of the cancer patient. It has been noted that altered interactions between unicellular and multi cellular genes drive hallmarks of transformation in cancers. And increased levels of telomerase are seen in majority of cancer patients. But right now cancer is 'the emperor of all agonies' . Perhaps  we can convert it as an emperor of all happiness by appropriate gene editing. The secretes for immortality are hidden and concealed in cancer. The aim is to recover and develop them. Binary fission or  division is the way unicellular organisms are becoming young. And there are genes in the biological system to achieve this. Reverting to amoebic reproduction is a real possibility. It is known that  if you have the genes everything is possible including immortality! A better  alternative for death and degeneration is binary fission (like the amoeba) and transformation to a child as you grow old. You may call the process as reverse ageing as well. This  alternative for death and degeneration may be imperfect to begin with , but can be perfected later. But there should be a will to do it.

Flowers are beautiful pretty and fragrant, but seeds and seedlings are not for all.

The beauty and fragrance  often hide the failed duty -  the reproduction!

Like the cancer hiding a new life. According to Sir Arthur Conan Doyle "There is no need for fiction in medicine for the facts will always beat anything you fancy" -- "Lead me from death to immortality"

      The e books are available free of cost for downloading.

      Divide and live is better than death and disintegration!

        Is there an alternative process to ageing and death?  Journal of American Geriatric Society January 2010 vol. 38.no.1, p.187

                                 "creativity is intelligence having fun"--- Albert Einstein 

https://www.smashwords.com/books/view/769583 [https://books.apple.com/us/book/x/id1329544147]

 Why Cancer ? in Indian Medical Association News Letter.

"WE CANNOT SOLVE OUR PROBLEMS  WITH THE SAME THINKING WE USED WHEN WE CREARTED THEM" 
Albert Einstein. 
 Cancer drug helps women to grow more eggs! - journal of human reproduction. 
It is an interesting  observation for me. 
 Scientists are  probably seeing some link with cancer and reproduction? Growth is a sign of life. If growth leads to death there should be some error somewhere. The drug combination known as ABVD increases ovum production in women; an accidental observation. Generally all drugs given for cancer and radiation affect human  reproduction. They often partly or completely destroy  ova and sperms, responsible for sexual reproduction. This is  because these therapies are  destroying  both asexual and sexual reproduction.(The antibiotics we take kill both harmful bacteria and the useful bacteria)The new combination of drug seems to destroy selectively only asexual reproduction (cancer). When asexual reproduction is arrested  the sexual reproduction  can get enhancement indirectly. Nature always wants reproduction and procreation to continue  and wants at least one method of reproduction be active in all organisms including humans as far as possible even in old age! Nature tries various techniques to encourage procreation and seems to give a lot of importance to future generations. Nature even sacrifice the present for a better future in certain species of Australian spiders & Praying mantis (sexual cannibalism).In nature's hands organisms are only carriers of DNA to next generation.
When a rose plant grows the older branches bend down and touch the soil. When  the bark is damaged due to frequent rubbing with soil roots emerge and gradually a new plant is formed by asexual reproduction. Suppose the gardener cuts the old overhanging branches preventing the asexual reproduction, more flowers shall be blooming from the young branches arising from the cut end, in an  attempt for sexual reproduction. In spite of increase in number of flowers, this attempt fails because of genetic deficiencies in the rose plant for sexual reproduction. We can expect that similar events shall occur  in humans also . But our  genetic deficiency is not in sexual reproduction,  but in asexual reproduction. Hence when sexual reproduction is stopped, restricted & blocked, the  inefficient asexual reproduction gets activated as in old age.  The old branches of plants and old men/women go for asexual reproduction while young branches and young men/women go for sexual reproduction! Reproduction is a very important function in nature and all efforts shall be made to achieve it.  Perhaps the only living organism which suppress the  normal reproductive instinct & reflexes and consider it as a great achievement  is humans.
Interestingly some of the medicines we use to treat infertility in women can induce cancer of ovaries. Perhaps our attempts to stimulate sexual reproduction are also stimulating asexual reproduction - the cancer!
Increased risk of cancer among azoospermic men -- Fertility and sterility.  Eisenberg, M.L. etl. (2013)
The authors have observed 2.2 fold higher cancer risk for azoospermic men & thought that it was due to possible common etiology. But it need not be due to the common etiology. We know that undescended testis does not have  a common etiology as cancer. But they do develop cancer  - the atavistic asexual reproduction. 
Another article in fertility & sterility shows the increasing risk of cancer stomach and testicular cancer in men with Peyrone's disease and erectile dysfunction. Here is one more instance of mother nature's attempt to compensate for loss of sexual reproduction.
 Cellular (Molecular) level proof?
Cancer cells break the most basic rules of behavior by which multi cellular organisms are built and maintained. And they exploit every kind of opportunity to do so. ( Albert B Johnson et. all Molecular biology of cell. 2002)It means that cancer cells behave  like the  unicellular organisms like amoeba in multiplication - the binary fission of unicellular organisms.
Even in the presence of oxygen the cancer cells use a less efficient method of energy generation, the glycolysis used by unicellular organisms like yeast. They do not use phosphorylation technique like the multi cellular organism. Cancer cells can eat another small cancer cell, similar to the amoeba eating small bacteria.
Interestingly a gravid uterus and a growing cancer are highly vascular without any inflammation, because reproductive process need lot of nourishment.
The p53 cancer suppressor  gene while suppressing the defective asexual reproduction process also correct the errors in sexual reproduction. The gene is known as a cancer killer gene . But in fact it is a reproduction regulating gene and in that process cancer cells are destroyed. This gene is responsible for prevention of birth defect like spina bifida.
Cancer cells have large nucleus life the sperms! There are several similarities between embryo genesis & oncogenesis.  
Ageing process can be reversed in mice - Journal Cell.
In fact in our own body at cellular level ageing process is reversed everyday during the growth process. When an old cell divides to form two young cells both do not have the old age characters of the extinguished mother cell, but are having young cell characters. Similarly when  amoeba undergo binary fission the ageing is reversed. If we can have an evolutionary through back and get this primitive reproductive process incorporated for multi cellular organism they also can reverse ageing process! Once all the cells are made young the organism becomes young! The serum level of  apoptosis inhibitor protein survivin is high cancer patient, because the body is attempting to prevent death of cells. In fact cancer seems to be an attempt for extension of life not for extinguishing life. It is not really  a growth dis order but a multiplication disorder producing abnormal cells having some of the qualities of sperms.  Successful genetic manipulation for achieving binary fission in humans and restarting life from child hood can solve many health problems we are facing to day. 
Death due to cancer is increasing every year.
Today the number of cancer death is more than the number of deaths caused by AIDS, Malaria and Tuberculosis combined together! (9.6 million proved cancer deaths in 2017) Interestingly in spite of all the 'preventive' measures taken by a highly aware and cancer conscious population, the incidence of cancer and death rate due to cancer are increasing. The cancer phobic people  get their organs (often reproductive & sex organs because more than 70% of cancer occur in these organs) removed before development of cancer in those organ. But still the incidence of cancer go on increasing while the human reproductive rate is going down every year. Obesity is also increasing in the population . And obesity is linked to cancer as well as sterility & impotence. According to an American survey there is sex recession in USA. Besides this life expectancy is increasing everywhere because of better health facility along with economic development. Why cancer death rate is increasing in spite of early detection and  better treatment? There is something wrong with the current  concepts about cancer itself. There seems to be  a link between falling reproductive rate and cancer. There is a huge reduction in attempts for reproduction (sex) as well as actual reproduction. Humans priority for sex and reproduction is much below that of the games like cricket, sports, cinema, personal hobbies,  money making, education, skill development etc. There are strong promoters for all these activities, but hardly any promoter for sex at home. Many people think children are not assets, but liability. Nature reacts to all our birth blocking devices and activities by trying other methods for procreation. Cancer can be explained as a manifestation of atavism due to the changed environment. We know that if we block any natural process nature shall try another route / method to achieve the objective. 'Sex recession' can produce 'cancer inflation'. Desire and sexual reflexes are often suppressed. (If we block the sun light to a plant from one direction the plant shall go to another direction. when the oxygen concentration of the air we breath reduces   our blood increase its capacity to carry oxygen. When water intake is poor we pass concentrated urine reducing the water content in urine etc. When we block the reproduction in bacteria with drugs they develop mutations  for alternate method of reproduction.)
We know that  cancer is not an ordinary disease. Perhaps we can call it as an inborn error of  asexual reproduction! We have  the inborn errors in anatomy like accessory mammary glands in the milk line (3rd & 4th breast in the axilla)  It is well known fact that we inherit several characters, partially or fully, from other living organisms. Binary fission is the reproductive process of amoeba and many other unicellular organisms. We have partially inherited it and it harms us. We have vestigial organs like appendix and coccyx occasionally giving painful diseases. Here is a vestigial process giving  rise to life threatening disease - cancer. (Similarly we have a vitamin c synthesis gene, but it is non functioning.) 
Today cancer is a frightening word. It is like a  heavy rain producing devastating floods in our life. We thought rain is bad and as children sang 'rain rain go away'. Now we know rain is not such a bad thing. So is cancer or asexual reproduction.  When cancer is not treated, this heavy shower of new cells kill us. But, is formation of  new young cells a bad concept? Is it done with a good intention to save us or with a bad intention to kill us? Why there is reactivation of telomerase enzyme in cancer cells? Converting these young cells to a young individual is something with in the capabilities of our scientist! I am sure they shall do it soon to save mankind and develop duel reproductive capability. We have enough stem cells in our body to develop the process of binary fission.
The Hindu mythology describe the process of an adult God becoming (transforming) a young child to eliminate the benevolent king of Kerala, Mavely. ( From the story of Onum festival) In nature we see a fatty caterpillar transforming to a light weight butterfly. By binary fission it is possible to become two mirror image children out of one adult. Obesity is an important risk factor for 13 types of cancers. Obesity may be a preperation for cancer.If you closely observe 'caterpillarisation' could be seen before development of certain cancers!
In an adult body usually growth is for repair and once repair is achieved growth stops. In cancer growth is for reproduction. Since this could not be achieved, growth and attempt for reproduction continue. And unfortunately this is  leading  to death of the person by the invasion of the fast multiplying cells attempting for asexual reproduction. There are several direct and indirect evidence to prove that cancer is a failed asexual reproduction of  humans. It was noticed that "many of the hallmarks of cancer are reminiscent of unicellular life, suggesting that neoplasm represents a type of through back or re-expression of ancestral trait". (Kimberly J Bussey. et.all).  Interestingly the human immune system knows that cancer is an attempt for asexual reproduction -- a very important function of a living organism. It is not an external attack . Hence the protective  immune system shall do nothing . The immune 'dog didn't bark'.  

If you closely observe there are lots of evidence as well as negative facts (absence of expected fact) to prove the reproductive link of cancer  in human system and they are  elaborated in the book "Why Cancer".  'Why cancer' tries to explain many unexplained observations about cancer, including the occasional spontaneous cure of cancer & the Peto's paradox. In the human life span the 'reproduction free period' is increasing day by day due to human intervention in the natural reproductive process and abnormal extension of the old age segment of human life. The mysteries of cancer can be unfolded with the new hypothesis. I consider cancer a genetically unstable growth promoted by the gametogenic genes, evolved while attempting asexual reproduction by mutations and is seen often when sexual reproduction is stopped as in old age. Wherever the fertility rate is below world average cancer rate is above world average.  

Journal publication: Cancer :The asexual reproduction hypothesis was published in the Journal of International Medical Science Academy 2020. 33(1): 37-39.  www.imsaonline.com

A rose flower is the failed attempt for sexual reproduction  &  cancer is the failed attempt for asexual reproduction!

Lateral thinking is a method of solving problems by making unusual or unexpected connections between ideas. It is very much similar to 'out of the box' thinking.

E. BOOK, ISBN: 9781370190973. Now the book can be down loaded from smashwords easily. 

Published through smashwords.
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There is a misconception that every living organism has to die one day or other!

Immortality is a series of the  two books -- Eye doctor out of the box & why cancer?

Immortality is possible!

"Look deep into nature and, then you will understand every thing better"
Albert Einstein.

Look deep into cancer and , then you shall see immortality!

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 Bewitching B.H.U. ISBN: 9781370165988 - e book.   ( https://www. smashwords.com)  This is the real story of struggle of the author for getting admission for  Master of Surgery course in  Ophthalmology  at Banaras Hindu University Varanasi. The interesting  train journey to BHU Varanasi ,the stay in the campus, arriving for  the written test at BHU more than half an hour late & writing the exam with special permission from director, the interview, journey back to CMC Vellore etc. are all described in detail in this book. The events described in the book  are about half a century old , but still relevant. It could be  published in  the year 2016 only due to various reasons.

 Varanasi is a unique ancient city in India and it is the holy city of Hindus, situated by the side of the river Ganges. Believing Hindus go to Varanasi to die there so that their souls shall go to heaven! Mark Twain described it 'Older than history, older than tradition, older than even legends and looks twice as old as all of them put together'.  B.H.U. is one of the old central universities  in India offering abundant opportunities to study a vast variety of subjects. It has a well planed   beautiful campus too. For a medical man it is important because the great Indian surgeon, Sushruta  practiced surgery in and around Varanasi during the vedic period. Every body in medical field knows his in-depth  knowledge , keen observations, great surgical skill and  astonishing ability in tackling surgical problems. The fact is that he was also a good physician and his observations about diabetes are remarkable. The medical institute originally started as Ayurvedic study center is now a full fledged modern medical institute with facilities for postgraduate studies in almost all subjects in modern medicine. For a serious  student who wishes to study, it is a well equipped student friendly  good residential university. Of course one should be focused to his subject of study and should be  able to shut the eyes towards all political diversions. The institute of medical science is being further developed and elevated  to  one of the  all India institute of medical sciences. Recently the city and university acquired lot of political importance because  the Indian  prime minister was elected to the parliament from this holy city.

The other E books by the same author are Eye doctor 'out of the box', Why cancer? and Odda days. Interview with the author was published in smashwords and can be viewed in   https;//www.smashwords.com/interview/EyeDoctorOutOfBox

An appreciation from Little Flower Hospital medical superintendent for the conferred F.R.C.S.

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Dr. Ittyerah Tholath  author of " Eye doctor out of the box" receive the  award for an  award                                                                                             from KSOS president Prof. Charles Scaria!

l

                                           

     Kolkata 2016 AIOS conference

 Receiving the award during 2016 A.I.O.S. conference Kolkatta            (A.I.O.S. is the world's largest life member ophthalmologists society)   

In the 75 years  history of All India Ophthalmological Society  Dr. Ittyerah is the second person from the Kerala state  to receive the   life time achievement award of this national organisation of eye surgeons.