Eye Doctor Out Of The Box

The Book

The Author

Out of the box thinking

The Interview

IMMORTALITY? Unfolding the mysteries of life and cancer! (Immortality hides in cancer!)

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Young for ever, natural death never!

The combination of 'Eye doctor out of the box' ISBN: 9781301878284 and 'Why cancer' ISBN: 9781370190973. e books by Ittyerah Tholath

Humans were afraid of death as and when they started living on the earth. As per records Gilgamesh, the legendary Mesopotamian king wanted to conquer death and live for ever. And his thoughts were carved on tablets written thousands of years before Christ. He hoped to conquer death , but could not achieve it. The immortality story of Hindu mythology is different. According to Hindu mythology Gods were mortal before drinking the 'Amrith' extracted by churning the milky ocean. After drinking the 'amrith' they became young and immortal. Millions of believing Hindus go on pilgrimage to the places where 'amrith' was spilled over to become healthy and to live long. They take bath in the holy river hoping to become young and immortal. When we analyze the mythology of Jews, Christians & Islam we see that Adam & Eve were immortal when created, and became mortal after eating the forbidden fruit. Hence as per mythology and religion humans can become immortal. There are scientific methods too to achieve immortality!

Modern medical doctors try to extend life and have succeeded in increasing life expectancy considerably. It means that they could postpone death, but could not eliminate death and destruction. There is no organism on earth other than humans to have a health system. The health system has achieved the goal of extending life expectancy and reducing infant mortality rate. But it could not reduce the number of patients and unhappy people on the globe. (The microbes without a health system remains young and energetic throughout their life.) The patients are often unhappy with our health delivery system. the doctors and health professionals are unhappy and often depressed. And the suicide rate of doctors' is more than double of the general population. The governments are strained because expenditure on health system is increasing rapidly. Why does this happen ? Because the aim of health system is wrong. The aim of health system should be a disease free young world. And all efforts should be in that direction. Delaying death shall increase the strains on health system. And immortality does not mean extension of the old age indefinitely.

Scientifically immortality is possible if we can rejuvenate as age advances by undergoing binary fission before reaching senility. ( We have a glorious amoebic heritage & immortality is in our genes. Mature amoeba divide and transform to two young amoeba) Immortality is with in our reach, but can be achieved only by hard scientific work with passion. We have successfully transferred genes from other living organisms. And editing of DNA and genes are being done in many labs. We have even edited the genes of human embryo successfully. Germ line editing, and incorporating binary fission genes is the next step. Hence with in few decades human immortality by incorporating binary fission genes will be a reality. Humans , 'being mortal', suffer from a lot of health problems and finally they are leading them to a miserable death. Humans becoming old leads to several geriatric diseases. Old population is vulnerable to many diseases including the COVID-19. Hence to become young and immortal is a necessity not only to prevent death but also for enjoying good health. We can adopt God's own ways for attaining immortality-- churning the ocean of genes and extract all the appropriate genes for the binary fission. Once these genes were incorporated in human genome humans can divide and become young as the age advances! 36 years is the average life expectancy of humans in unprotected environment and if we can divide at 36 years there will not be any old humans! Becoming young by division is nature's law. If we follow the natures way immortality is not impossible!

Both the books refer to the possibilities of immortality by changing genes (germ line transfer), changing style of procreation, and transformation. Asexual reproduction hypothesis of cancer origin was published in the Journal of International medical science Academy (www.jimsaonline.com or www.imsaonline.com). HeLa cells , the cells derived from the cancer patient , Henrietta Lacks have become immortal and are continuing to live in laboratories many years after the death of the cancer patient. It has been noted that altered interactions between unicellular and multi cellular genes drive hallmarks of transformation in cancers. And increased levels of telomerase are seen in majority of cancer patients. But right now cancer is 'the emperor of all agonies' . Perhaps we can convert it as an emperor of all happiness by appropriate gene editing. The secretes for immortality are hidden and concealed in cancer. The aim is to recover and develop them. Binary fission or division is the way unicellular organisms are becoming young. And there are genes in the biological system to achieve this. Reverting to amoebic reproduction is a real possibility. It is known that if you have the genes everything is possible including immortality! A better alternative for death and degeneration is binary fission (like the amoeba) and transformation to a child as you grow old. You may call the process as reverse ageing as well. This alternative for death and degeneration may be imperfect to begin with , but can be perfected later. But there should be a will to do it.

Flowers are beautiful pretty and fragrant, but seeds and seedlings are not for all.

The beauty and fragrance often hide the failed duty - the reproduction!

Like the cancer hiding a new life. According to Sir Arthur Conan Doyle "There is no need for fiction in medicine for the facts will always beat anything you fancy" -- "Lead me from death to immortality"

The e books are available free of cost for downloading.

Divide and live is better than death and disintegration!

Is there an alternative process to ageing and death? Journal of American Geriatric Society January 2010 vol. 38.no.1, p.187

"creativity is intelligence having fun"--- Albert Einstein

WHY CANCER? ISBN:9781370190973; Lateral thoughts on cancer & reproduction.

https://www.smashwords.com/books/view/769583 [https://books.apple.com/us/book/x/id1329544147]

Why Cancer ? in Indian Medical Association News Letter.

"WE CANNOT SOLVE OUR PROBLEMS WITH THE SAME THINKING WE USED WHEN WE CREARTED THEM"
Albert Einstein.
Cancer drug helps women to grow more eggs! - journal of human reproduction.
It is an interesting observation for me.
Scientists are probably seeing some link with cancer and reproduction? Growth is a sign of life. If growth leads to death there should be some error somewhere. The drug combination known as ABVD increases ovum production in women; an accidental observation. Generally all drugs given for cancer and radiation affect human reproduction. They often partly or completely destroy ova and sperms, responsible for sexual reproduction. This is because these therapies are destroying both asexual and sexual reproduction.(The antibiotics we take kill both harmful bacteria and the useful bacteria)The new combination of drug seems to destroy selectively only asexual reproduction (cancer). When asexual reproduction is arrested the sexual reproduction can get enhancement indirectly. Nature always wants reproduction and procreation to continue and wants at least one method of reproduction be active in all organisms including humans as far as possible even in old age! Nature tries various techniques to encourage procreation and seems to give a lot of importance to future generations. Nature even sacrifice the present for a better future in certain species of Australian spiders & Praying mantis (sexual cannibalism).In nature's hands organisms are only carriers of DNA to next generation.
When a rose plant grows the older branches bend down and touch the soil. When the bark is damaged due to frequent rubbing with soil roots emerge and gradually a new plant is formed by asexual reproduction. Suppose the gardener cuts the old overhanging branches preventing the asexual reproduction, more flowers shall be blooming from the young branches arising from the cut end, in an attempt for sexual reproduction. In spite of increase in number of flowers, this attempt fails because of genetic deficiencies in the rose plant for sexual reproduction. We can expect that similar events shall occur in humans also . But our genetic deficiency is not in sexual reproduction, but in asexual reproduction. Hence when sexual reproduction is stopped, restricted & blocked, the inefficient asexual reproduction gets activated as in old age. The old branches of plants and old men/women go for asexual reproduction while young branches and young men/women go for sexual reproduction! Reproduction is a very important function in nature and all efforts shall be made to achieve it. Perhaps the only living organism which suppress the normal reproductive instinct & reflexes and consider it as a great achievement is humans.
Interestingly some of the medicines we use to treat infertility in women can induce cancer of ovaries. Perhaps our attempts to stimulate sexual reproduction are also stimulating asexual reproduction - the cancer!
Increased risk of cancer among azoospermic men -- Fertility and sterility.  Eisenberg, M.L. etl. (2013)
The authors have observed 2.2 fold higher cancer risk for azoospermic men & thought that it was due to possible common etiology. But it need not be due to the common etiology. We know that undescended testis does not have a common etiology as cancer. But they do develop cancer - the atavistic asexual reproduction.
Another article in fertility & sterility shows the increasing risk of cancer stomach and testicular cancer in men with Peyrone's disease and erectile dysfunction. Here is one more instance of mother nature's attempt to compensate for loss of sexual reproduction.
Cellular (Molecular) level proof?
Cancer cells break the most basic rules of behavior by which multi cellular organisms are built and maintained. And they exploit every kind of opportunity to do so. ( Albert B Johnson et. all Molecular biology of cell. 2002)It means that cancer cells behave like the unicellular organisms like amoeba in multiplication - the binary fission of unicellular organisms.
Even in the presence of oxygen the cancer cells use a less efficient method of energy generation, the glycolysis used by unicellular organisms like yeast. They do not use phosphorylation technique like the multi cellular organism. Cancer cells can eat another small cancer cell, similar to the amoeba eating small bacteria.
Interestingly a gravid uterus and a growing cancer are highly vascular without any inflammation, because reproductive process need lot of nourishment.
The p53 cancer suppressor gene while suppressing the defective asexual reproduction process also correct the errors in sexual reproduction. The gene is known as a cancer killer gene . But in fact it is a reproduction regulating gene and in that process cancer cells are destroyed. This gene is responsible for prevention of birth defect like spina bifida.
Cancer cells have large nucleus life the sperms! There are several similarities between embryo genesis & oncogenesis.
Ageing process can be reversed in mice - Journal Cell.
In fact in our own body at cellular level ageing process is reversed everyday during the growth process. When an old cell divides to form two young cells both do not have the old age characters of the extinguished mother cell, but are having young cell characters. Similarly when amoeba undergo binary fission the ageing is reversed. If we can have an evolutionary through back and get this primitive reproductive process incorporated for multi cellular organism they also can reverse ageing process! Once all the cells are made young the organism becomes young! The serum level of apoptosis inhibitor protein survivin is high cancer patient, because the body is attempting to prevent death of cells. In fact cancer seems to be an attempt for extension of life not for extinguishing life. It is not really a growth dis order but a multiplication disorder producing abnormal cells having some of the qualities of sperms. Successful genetic manipulation for achieving binary fission in humans and restarting life from child hood can solve many health problems we are facing to day.
Death due to cancer is increasing every year.
Today the number of cancer death is more than the number of deaths caused by AIDS, Malaria and Tuberculosis combined together! (9.6 million proved cancer deaths in 2017) Interestingly in spite of all the 'preventive' measures taken by a highly aware and cancer conscious population, the incidence of cancer and death rate due to cancer are increasing. The cancer phobic people get their organs (often reproductive & sex organs because more than 70% of cancer occur in these organs) removed before development of cancer in those organ. But still the incidence of cancer go on increasing while the human reproductive rate is going down every year. Obesity is also increasing in the population . And obesity is linked to cancer as well as sterility & impotence. According to an American survey there is sex recession in USA. Besides this life expectancy is increasing everywhere because of better health facility along with economic development. Why cancer death rate is increasing in spite of early detection and better treatment? There is something wrong with the current concepts about cancer itself. There seems to be a link between falling reproductive rate and cancer. There is a huge reduction in attempts for reproduction (sex) as well as actual reproduction. Humans priority for sex and reproduction is much below that of the games like cricket, sports, cinema, personal hobbies, money making, education, skill development etc. There are strong promoters for all these activities, but hardly any promoter for sex at home. Many people think children are not assets, but liability. Nature reacts to all our birth blocking devices and activities by trying other methods for procreation. Cancer can be explained as a manifestation of atavism due to the changed environment. We know that if we block any natural process nature shall try another route / method to achieve the objective. 'Sex recession' can produce 'cancer inflation'. Desire and sexual reflexes are often suppressed. (If we block the sun light to a plant from one direction the plant shall go to another direction. when the oxygen concentration of the air we breath reduces our blood increase its capacity to carry oxygen. When water intake is poor we pass concentrated urine reducing the water content in urine etc. When we block the reproduction in bacteria with drugs they develop mutations for alternate method of reproduction.)
We know that cancer is not an ordinary disease. Perhaps we can call it as an inborn error of asexual reproduction! We have the inborn errors in anatomy like accessory mammary glands in the milk line (3rd & 4th breast in the axilla) It is well known fact that we inherit several characters, partially or fully, from other living organisms. Binary fission is the reproductive process of amoeba and many other unicellular organisms. We have partially inherited it and it harms us. We have vestigial organs like appendix and coccyx occasionally giving painful diseases. Here is a vestigial process giving rise to life threatening disease - cancer. (Similarly we have a vitamin c synthesis gene, but it is non functioning.)
Today cancer is a frightening word. It is like a heavy rain producing devastating floods in our life. We thought rain is bad and as children sang 'rain rain go away'. Now we know rain is not such a bad thing. So is cancer or asexual reproduction. When cancer is not treated, this heavy shower of new cells kill us. But, is formation of new young cells a bad concept? Is it done with a good intention to save us or with a bad intention to kill us? Why there is reactivation of telomerase enzyme in cancer cells? Converting these young cells to a young individual is something with in the capabilities of our scientist! I am sure they shall do it soon to save mankind and develop duel reproductive capability. We have enough stem cells in our body to develop the process of binary fission.
The Hindu mythology describe the process of an adult God becoming (transforming) a young child to eliminate the benevolent king of Kerala, Mavely. ( From the story of Onum festival) In nature we see a fatty caterpillar transforming to a light weight butterfly. By binary fission it is possible to become two mirror image children out of one adult. Obesity is an important risk factor for 13 types of cancers. Obesity may be a preperation for cancer.If you closely observe 'caterpillarisation' could be seen before development of certain cancers!
In an adult body usually growth is for repair and once repair is achieved growth stops. In cancer growth is for reproduction. Since this could not be achieved, growth and attempt for reproduction continue. And unfortunately this is leading to death of the person by the invasion of the fast multiplying cells attempting for asexual reproduction. There are several direct and indirect evidence to prove that cancer is a failed asexual reproduction of humans. It was noticed that "many of the hallmarks of cancer are reminiscent of unicellular life, suggesting that neoplasm represents a type of through back or re-expression of ancestral trait". (Kimberly J Bussey. et.all). Interestingly the human immune system knows that cancer is an attempt for asexual reproduction -- a very important function of a living organism. It is not an external attack . Hence the protective immune system shall do nothing . The immune 'dog didn't bark'.

If you closely observe there are lots of evidence as well as negative facts (absence of expected fact) to prove the reproductive link of cancer in human system and they are elaborated in the book "Why Cancer". 'Why cancer' tries to explain many unexplained observations about cancer, including the occasional spontaneous cure of cancer & the Peto's paradox. In the human life span the 'reproduction free period' is increasing day by day due to human intervention in the natural reproductive process and abnormal extension of the old age segment of human life. The mysteries of cancer can be unfolded with the new hypothesis. I consider cancer a genetically unstable growth promoted by the gametogenic genes, evolved while attempting asexual reproduction by mutations and is seen often when sexual reproduction is stopped as in old age. Wherever the fertility rate is below world average cancer rate is above world average.

Journal publication: Cancer :The asexual reproduction hypothesis was published in the Journal of International Medical Science Academy 2020. 33(1): 37-39. www.imsaonline.com

A rose flower is the failed attempt for sexual reproduction & cancer is the failed attempt for asexual reproduction!

Lateral thinking is a method of solving problems by making unusual or unexpected connections between ideas. It is very much similar to 'out of the box' thinking.

E. BOOK, ISBN: 9781370190973. Now the book can be down loaded from smashwords easily.

Published through smashwords.
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https://www.smashwords.com/interview/EyeDoctorOutOfBox

There is a misconception that every living organism has to die one day or other!

Immortality is a series of the two books -- Eye doctor out of the box & why cancer?

Immortality is possible!

"Look deep into nature and, then you will understand every thing better"
Albert Einstein.

Look deep into cancer and , then you shall see immortality!

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Bewitching B.H.U. ISBN 9781370165988 -- An educational pilgrimage to Varanasi.

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Bewitching B.H.U. ISBN: 9781370165988 - e book. ( https://www. smashwords.com) This is the real story of struggle of the author for getting admission for Master of Surgery course in Ophthalmology at Banaras Hindu University Varanasi. The interesting train journey to BHU Varanasi ,the stay in the campus, arriving for the written test at BHU more than half an hour late & writing the exam with special permission from director, the interview, journey back to CMC Vellore etc. are all described in detail in this book. The events described in the book are about half a century old , but still relevant. It could be published in the year 2016 only due to various reasons.

Varanasi is a unique ancient city in India and it is the holy city of Hindus, situated by the side of the river Ganges. Believing Hindus go to Varanasi to die there so that their souls shall go to heaven! Mark Twain described it 'Older than history, older than tradition, older than even legends and looks twice as old as all of them put together'. B.H.U. is one of the old central universities in India offering abundant opportunities to study a vast variety of subjects. It has a well planed beautiful campus too. For a medical man it is important because the great Indian surgeon, Sushruta practiced surgery in and around Varanasi during the vedic period. Every body in medical field knows his in-depth knowledge , keen observations, great surgical skill and astonishing ability in tackling surgical problems. The fact is that he was also a good physician and his observations about diabetes are remarkable. The medical institute originally started as Ayurvedic study center is now a full fledged modern medical institute with facilities for postgraduate studies in almost all subjects in modern medicine. For a serious student who wishes to study, it is a well equipped student friendly good residential university. Of course one should be focused to his subject of study and should be able to shut the eyes towards all political diversions. The institute of medical science is being further developed and elevated to one of the all India institute of medical sciences. Recently the city and university acquired lot of political importance because the Indian prime minister was elected to the parliament from this holy city.

The other E books by the same author are Eye doctor 'out of the box', Why cancer? and Odda days. Interview with the author was published in smashwords and can be viewed in https;//www.smashwords.com/interview/EyeDoctorOutOfBox

An appreciation from Little Flower Hospital medical superintendent for the conferred F.R.C.S.

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Life time achievement award from All India Ophthalmological Society. (A.I.O.S.) 2015

Dr. Ittyerah Tholath author of " Eye doctor out of the box" receive the award for an award from KSOS president Prof. Charles Scaria!

Kolkata 2016 AIOS conference

Receiving the award during 2016 A.I.O.S. conference Kolkatta (A.I.O.S. is the world's largest life member ophthalmologists society)

In the 75 years history of All India Ophthalmological Society Dr. Ittyerah is the second person from the Kerala state to receive the life time achievement award of this national organisation of eye surgeons.

Ponnada from Cardinal Mar George Alenchery , I.J.O. editors ,& celebrations of 50 years of publication of I.J.O.

when I joined at Little flower hospital in the year 1975, Angamaly was a small village with a relatively large mission hospital having a hypertrophied ophthalmic department.The growth rate of eye department in the following years were much more than the growth of other departments. All the directors were very keen to get other departments also grow at the same speed as ophthalmic department.But the disproportionate growth continued and many persons were unhappy about it.The hospital had almost all major departments functioning fairly well.But often people called it as 'Angamaly Eye hospital' since eye department under Dr. Tony Fernandez was attracting patients from all over India and abroad.I am indeed happy to work in this hospital at various capacities under different directors contributing to the growth and prosperity of the department and the hospital.

With cardinal Mar George Alenchery, other bishops & director L.F.Hospital Angamaly

41 years at Little Flower Hospital Angamaly

2016 . A.I.O.S Kolkatta - Former editors & the emeritus editors of I.J.O.

President of India A.P.J. Kalam honoring past chief editor of I.J.O. Dr. Ittyerah during the celebrations of 50 years of publication at Hyderabad (19/01/2004) --The short yet valuable interaction with the honorable president of India professor
Kalam gave wings to my big dreams .

TACOPSIA Oration 2012- Untold experience ,the failure stories

Receiving the Trichur academy of ophthalmology award & ponnada 2012 at Trichur Kerala

'Happiness from the bottom of the heart'
Several times rejected paper ( Is there an alternative to ageing and death?) was finally published in the journal of American geriatric society in 2010. Failure is the real stepping stone to success! Many other failure (error) stories which were rarely discussed and exposed, were presented during the oration (untold experience) by the author of 'eye doctor out of the box'. From errors and mistakes we learn a lot.

To err is human ............ Do gods commit errors? what are miscarriages and congenital anomalies?

According to evolutionary developmental biologist Sean B Carroll " Look around you at all the beauty, complexity, and variety of life , we live in a world of mistakes, governed by chance"